The clinical studies on this page are medical/technical in nature. Please see our Cancer Case Histories page for very interesting and easy to follow case histories on the effectiveness of Jiva Ingredients.
 - Aassociation of activated transcription factor nuclear factor kB with chemoradiation resistance a.pdf |
| - All pathways to cancer apoptosis meeting in Thiruvananthapuram (India).pdf |
| - Chemosensitization and radiosensitization of tumors by plant polyphenols.pdf |
| - From ancient medicine to modern medicine- Ayurvedic concepts of health and their role in inflamma.pdf |
| - From traditional Ayurvedic medicine to modern medicine- identification of therapeutic targets for.pdf |
| - Inflammation and cancer- how hot is the link.pdf |
| - Molecular targets of dietary agents for prevention and therapy for cancer.pdf |
| - Molecular targets of dietary agents for prevention and therapy for cancer.pdf |
| - Nuclear Factor-kB- A holy grail in cancer prevention and therapy.pdf |
| - Nuclear Factor-kB as target for chemoprevention.pdf |
| - Nuclear factor-kB is frequently expressed in lung cancer and preneoplastic lesions.pdf |
| - Pretherapy nuclear factor-kB status, chemoradiation resistance, and metastatic progression in eso.pdf
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| - Prevention and therapeutic effects of plant polyphenols through suppression of nuclear factor-kap.pdf |
| - Pro-apoptotic and anti-apoptotic effects of tumor necrosis factor in tumor cells.pdf |
| - Redox regulation of apoptotsis by members of the TNF superfamily.pdf |
| - Targeting cell signaling pathways for drug discovery- an old lock needs a new key.pdf |
| - Targeting cell signaling pathways for drug discovery- an old lock needs a new key.pdf |
| - Targeted deletion of MKK4 gene potentiates TNF-induced apoptosis through the down-regulation of N.pdf |
| - TNF blockade- an inflammatory issue.pdf |
Front Biosci. 2008 Jan 1;13:2191-202.
Cell cycle control as a basis for cancer chemoprevention through dietary agents.
Meeran SM, Katiyar SK.
Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL35294, USA.
The development of cancer is associated with disorders in the regulation of the cell cycle. The purpose of this review is to briefly summarize the known sequence of events that regulate cell cycle progression with an emphasis on the checkpoints and the mechanisms cell employ to insure DNA stability in the face of genotoxic stress. Key transitions in the cell cycle are regulated by the activities of various protein kinase complexes composed of cyclin and cyclin-dependent kinases (CDK) molecules. The cyclins are CDK binding partners which are required for kinase activity and their protein levels are intimately linked to the cell cycle stage. CDK activity can be regulated by other mechanisms, such as phosphorylation events, that may contribute to deregulation of cell cycle and the development of cancer.
While fruits and vegetables are recommended for prevention of cancer, their active ingredients and mechanisms of action are less well understood. Here, we briefly present evidence that dietary agents identified from fruits and vegetables can act to modulate the effects of deregulated cell cycle checkpoints, and that this may contribute to the prevention of cancer. The agents include apigenin (celery, parsley), curcumin (turmeric), (-)-epigallocatechin-3-gallate (green tea), resveratrol (red grape, peanuts and berries), genistein (soybean), and silymarin (milk thistle). The teachings of Hippocrates are still true "let food be thy medicine and medicine be thy food".
Cancer Letters
Volume 215, Issue 2 , 25 November 2004, Pages 129-140
Role of chemopreventive agents in cancer therapy
Thambi Doraia and Bharat B. Aggarwalb, ,
Comprehensive Cancer Center, Our Lady of Mercy Medical Center, New York Medical College, Bronx, NY 10466, USA
bCytokine Research Section, Department of Experimental therapeutics, The University of Texas M.D. Anderson Cancer Center, Box 143, 1515 Holcombe Boulevard, Houston, TX 77030, USA View this entire study here.
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